Oncogenic Roles of PRL-3 in FLT3-ITD Induced Acute Myeloid Leukemia
نویسندگان
چکیده
Reviewer 2 also feels that some conclusions are invalid due to experimental flaws. Again, without going into detail I would mention his/her perplexities on the conclusion drawn from the immunoprecipitation experiments depicted in Fig. 2. Additionally, Reviewer 2 suggests a number of crucial experiments required to show that PRL-3 mediates up regulation of c-Jun through JNK/ERK. This Reviewer also lists other critical points that require your intervention.
منابع مشابه
Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia
FLT3-ITD mutations are prevalent mutations in acute myeloid leukaemia (AML). PRL-3, a metastasis-associated phosphatase, is a downstream target of FLT3-ITD. This study investigates the regulation and function of PRL-3 in leukaemia cell lines and AML patients associated with FLT3-ITD mutations. PRL-3 expression is upregulated by the FLT3-STAT5 signalling pathway in leukaemia cells, leading an ac...
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